Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
2020
Authors:
Stikić, Radmila I.Milinčić, Danijel D.
Kostić, Aleksandar Ž.
Jovanović, Zorica B.
Gašić, Uroš
Tešić, Živoslav Lj.
Djordjević, Nataša Z.
Savić, Sladjana K.
Czekus, Borisz G.
Pešić, Mirjana
Document Type:
Article (Accepted Version)
,
© 2020 Cereals & Grains Association.
Metadata
Show full item recordAbstract:
Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. 13 phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration, and time‐dependent effects were more expressed in Puno extracts. The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.
Keywords:
Antioxidant activity; Colon cancer; Cytotoxic activity; Flavonoids; Phenolic acids; Quinoa seedSource:
Cereal Chemistry, 2020, 97, 3, cche.10278-633Funding / projects:
- Biotechnological approaches for overcoming effects of drought on agricultural production in Serbia (RS-MESTD-Technological Development (TD or TR)-31005)
- Investigating the possibility of using contaminated waters for cultivation of pseudocereals (RS-MESTD-Technological Development (TD or TR)-31006)
- Utilization of plant sources of protein, dietary fiber and antioxidants in food production (RS-MESTD-Technological Development (TD or TR)-31069)
- Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-MESTD-Basic Research (BR or ON)-172017)
- Physiological, chemical and molecular analysis of the diversity of selected rare and endangered plant species and application of biotechnology for ex situ conservation and production of biologically active compounds (RS-MESTD-Basic Research (BR or ON)-173024)
- Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1002/cche.10278
ISSN: 0009-0352
WoS: 000521447000001
Scopus: 2-s2.0-85082187869
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cche.10278https://radar.ibiss.bg.ac.rs/handle/123456789/3639