Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
2020
Autori:
Stikić, Radmila I.Milinčić, Danijel D.
Kostić, Aleksandar Ž.
Jovanović, Zorica B.
Gašić, Uroš
Tešić, Živoslav Lj.
Djordjević, Nataša Z.
Savić, Sladjana K.
Czekus, Borisz G.
Pešić, Mirjana
Tip dokumenta:
Članak u časopisu (Recenzirana verzija)
,
© 2020 Cereals & Grains Association.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. 13 phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration, and time‐dependent effects were more expressed in Puno extracts. The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.
Ključne reči:
Antioxidant activity; Colon cancer; Cytotoxic activity; Flavonoids; Phenolic acids; Quinoa seedIzvor:
Cereal Chemistry, 2020, 97, 3, cche.10278-633Finansiranje / projekti:
- Savremeni biotehnološki pristup rešavanja problema suše u poljoprivredi Srbije (RS-MESTD-Technological Development (TD or TR)-31005)
- Ispitivanje mogućnosti korišćenja kontaminiranih voda za gajenje alternativnih, zdravstveno bezbednih žita (RS-MESTD-Technological Development (TD or TR)-31006)
- Korišćenje biljnih izvora proteina, dijetalnih vlakana i antioksidanasa u proizvodnji hrane (RS-MESTD-Technological Development (TD or TR)-31069)
- Korelacija strukture i osobina prirodnih i sintetičkih molekula i njihovih kompleksa sa metalima (RS-MESTD-Basic Research (BR or ON)-172017)
- Fiziološka, hemijska i molekularna analiza diverziteta odabranih retkih i ugroženih biljnih vrsta u cilju ex situ zaštite i produkcije biološki aktivnih jedinjenja (RS-MESTD-Basic Research (BR or ON)-173024)
- Molekularno fiziološki biomonitoring aerobnih organizama zasnovan na određivanju biohemijskih biomarkera oksidacionog stresa (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1002/cche.10278
ISSN: 0009-0352
WoS: 000521447000001
Scopus: 2-s2.0-85082187869
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cche.10278https://radar.ibiss.bg.ac.rs/handle/123456789/3639