Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
2020
Autori:
Đurašević, SinišaNikolić, Gorana
Todorović, Ana
Drakulić, Dunja
Pejić, Snežana
Martinović, Vesna
Mitić-Ćulafić, Dragana
Milić, Dragana
Kop, Tatjana J.
Jasnić, Nebojša
Đorđević, Jelena
Todorović, Zoran
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2020 Elsevier Ltd
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
Ključne reči:
Fullerene C60; Glucose homeostasis; Gut microbiota; Lipid homeostasis; RatsIzvor:
Food and Chemical Toxicology, 2020, 140, 111302-Finansiranje / projekti:
- Dizajn, sinteza i ispitivanje nanomolekulskih mašina na bazi fulerena (RS-MESTD-Basic Research (BR or ON)-172002)
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Efekat metaboličkih i nemetaboličkih stresora na ekspresiju i delovanje neuroendokrinih regulatora energetske homeostaze (RS-MESTD-Basic Research (BR or ON)-173023)
- Signalni molekuli u dijabetesu: identifikacija potencijalnih bioloških markera uključenih u modifikaciju i integraciju signalnih puteva u cilju predikcije i intervencije u dijabetesu (RS-MESTD-Basic Research (BR or ON)-173020)
- Biološki aktivni prirodni proizvodi kao potencijalni izvori novih lekova i dijetetskih suplemenata (RS-MESTD-Basic Research (BR or ON)-172058)
DOI: 10.1016/j.fct.2020.111302
ISSN: 0278-6915
PubMed: 32234425