Chronic Stress Potentiates High Fructose-Induced Lipogenesis in Rat Liver and Kidney.
2020
Аутори:
Vojnović-Milutinović, DanijelaBrkljačić, Jelena
Teofilović, Ana
Bursać, Biljana
Radovanović, Marina
Gligorovska, Ljupka
Kovačević, Sanja
Đorđević, Ana
Preitner, Frederic
Tappy, Luc
Matić, Gordana
Veličković, Nataša
Тип документа:
Чланак у часопису (Рецензирана верзија)
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© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Метаподаци
Приказ свих података о документуАпстракт:
SCOPE Intake of fructose-sweetened beverages and chronic stress (CS) both increase risk of cardiometabolic diseases. The aim is to investigate whether these factors synergistically perturb lipid metabolism in rat liver and kidney. METHODS AND RESULTS Fractional de novo lipogenesis (fDNL), intrahepatic- and intrarenal-triglycerides (IHTG and IRTG), de novo palmitate (DNPalm) content, FA composition, VLDL-TGs kinetics, and key metabolic gene expression at the end of the feeding and non-feeding phases in rats exposed to standard chow diet, chow diet + CS, 20% liquid high-fructose supplementation (HFr), or HFr+CS are measured. HFr induces hypertriglyceridemia, up-regulates fructose-metabolism and gluconeogenic enzymes, increases IHTG and DNPalm content in IHTG and IRTG, and augments fDNL at the end of the feeding phase. These changes are diminished after the non-feeding phase. CS does not exert such effects, but when combined with HFr, it reduces IHTG and visceral adiposity, enhances lipogenic gene expression and fDNL, and increases VLDL-DNPalm secretion. CONCLUSION Liquid high-fructose supplementation increases IHTG and VLDL-TG secretion after the feeding phase, the latter being the result of stimulated hepatic and renal DNL. Chronic stress potentiates the effects of high fructose on fDNL and export of newly synthesized VLDL-TGs, and decreases fructose-induced intrahepatic TG accumulation after the feeding phase.
Напомена:
This is the peer reviewed version of the following article: Vojnović Milutinović D, Brkljačić J, Teofilović A, Bursać B, Nikolić M, Gligorovska L, Kovačević S, Djordjevic A, Preitner F, Tappy L, Matić G, Veličković N. Chronic Stress Potentiates High Fructose-Induced Lipogenesis in Rat Liver and Kidney. Mol Nutr Food Res. 2020;e1901141, which has been published in final form at http://dx.doi.org/10.1002/mnfr.201901141. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Кључне речи:
Chronic stress; High-fructose supplementation; Kidneys; Lipogenesis; LiverИзвор:
Molecular Nutrition & Food Research, 2020, 64, 13, e1901141-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- SCOPES JRP. Grant Number: IZ73ZO_152331
DOI: 10.1002/mnfr.201901141
ISSN: 1613-4125
PubMed: 32379936
WoS: 000539005500001
Scopus: 2-s2.0-85086171965
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201901141http://www.ncbi.nlm.nih.gov/pubmed/32379936
https://radar.ibiss.bg.ac.rs/handle/123456789/3702