The antioxidant potential of Lactarius deterrimus in diabetes
2020
Authors:
Arambašić Jovanović, JelenaMihailović, Mirjana
Dinić, Svetlana
Grdović, Nevena
Uskoković, Aleksandra
Poznanović, Goran
Vidaković, Melita
Contributors
Preedy, Victor R.Document Type:
Book part (Published version)
,
© 2020 Elsevier Inc.
Metadata
Show full item recordAbstract:
Diabetes is characterized by impaired pancreatic insulin production or an insufficient cellular response to insulin. Hyperglycemia is the main cause of diabetic complications affecting vascular system, kidneys, eyes, peripheral nerves, liver and gastrointestinal system. Hyperglycemia induces overproduction of reactive oxygen species, resulting in impaired cellular function and altered cell signaling. High intracellular glucose levels activate the formation of advanced glycation end-products, the polyol pathway, the hexosamine pathway, and the protein kinase C pathway, affecting gene expression and activity of different regulator proteins. Medicinal mushrooms as source of metabolites (minerals, vitamins, polyphenols, flavonoids, terpenes, alkaloids) have been used in traditional medicine in diabetes treatment for centuries. Lactarius species exhibit a variety of biological activities, including antioxidant, antitumor, and immunostimulatory actions. In this chapter the antioxidant capacity of Lactarius deterrimus and its potential to attenuate the processes that underlie the development and progression of diabetes and diabetes-induced complications will be examined.
Keywords:
Diabetes; Lactarius deterrimus; Hyperglycemia; Oxidative stress; β-cell survival; Advanced glycated end-products; Reactive oxygen speciesFunding / projects:
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-MESTD-Basic Research (BR or ON)-173020)
In:
- Preedy VR, editor. Diabetes: Oxidative Stress and Dietary Antioxidants. 2nd ed. San Diego : Elsevier Science & Technology; 2020. p. 265-73.