Short- and Long-Term Exposure to Alternating Magnetic Field (50 Hz, 0.5 mT) Affects Rat Pituitary ACTH Cells: Stereological Study
2016
Autori:
Rauš Balind, SnežanaManojlović-Stojanoski, Milica
Milošević, Verica
Todorović, Dajana
Nikolić, Ljiljana
Petković, Branka
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2014 Wiley Periodicals, Inc.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The aim of the present study was to determine does extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affect pituitary adrenocorticotroph (ACTH) cells in adult animals. We performed two series of experiments: (1) short-term exposure of 3-month-old rats to ELF-MF for 1 and 7 days, and (2) long-term exposure of rats to ELF-MF from their conception to 3 months of age. Stereological study was performed on immunolabeled pituitary ACTH cells. The total number and volume of ACTH cells, the volume of their nuclei and pituitary volume were measured. ELF-MF exposure for 1 day significantly decreased total number and volume of ACTH cells, the volume of their nuclei, as well as pituitary volume. ELF-MF exposure for 7 days significantly reduced only the volume of ACTH cells. Life-long exposure to ELF-MF induced decrease in the volume of ACTH cells and pituitary volume. We can conclude that the applied ELF-MF has a strong influence on morphometrical parameters of the pituitary ACTH cells and could be considered as a stressogenic factor.
Ključne reči:
Extremely low frequency magnetic field; ACTH cells; Stereology; PituitaryIzvor:
Environmental Toxicology, 2016, 31, 4, 461-468Finansiranje / projekti:
- Uticaj magnetnih polja i drugih sredinskih stresora na fiziološke odgovore i ponašanje različitih vrsta (RS-MESTD-Basic Research (BR or ON)-173027)
DOI: 10.1002/tox.22059
ISSN: 1520-4081; 1520-4081
PubMed: 25346405
WoS: 000372318300008
Scopus: 2-s2.0-84960472575
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22059https://radar.ibiss.bg.ac.rs/handle/123456789/3776