Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils
2013
Тип документа:
Чланак у часопису (Објављена верзија)
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© Springer Science+Business Media New York 2013
Метаподаци
Приказ свих података о документуАпстракт:
The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils. Nitric oxide (NO) level, superoxide (O2-) production, superoxide dismutase (SOD) activity, and index of lipid peroxidation (ILP) were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This effect was correlated with the value of magnetic induction and was higher in middle-aged gerbils. Three days after cessation of exposure, the values of examined parameters were closer to control levels. In adult gerbils, the effect of ELF-MF of 0.1 mT on NO level, O2- production and SOD activity was almost fully disappeared, and ILP was at the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present but to a lesser degree than those observed immediately after cessation of exposure. These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.
Кључне речи:
50 Hz magnetic field; Oxidative stress; Brain; Aging; GerbilsИзвор:
Cell Biochemistry and Biophysics, 2013, 66, 3, 513-521Финансирање / пројекти:
- Утицај магнетних поља и других срединских стресора на физиолошке одговоре и понашање различитих врста (RS-MESTD-Basic Research (BR or ON)-173027)
- MMA Grant (VMA/06-10/B.4)
DOI: 10.1007/s12013-012-9498-z
ISSN: 1085-9195
PubMed: 23292355
WoS: 000322526500009
Scopus: 2-s2.0-84880934332
URI
https://link.springer.com/article/10.1007/s12013-012-9498-zhttps://radar.ibiss.bg.ac.rs/handle/123456789/3785