Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia
2012
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2011 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The purpose of this study was to evaluate behavioural effects of an extremely low frequency magnetic field (ELF-MF) in 3-month-old Mongolian gerbils submitted to global cerebral ischemia. After 10-min occlusion of both common carotid arteries, the gerbils were placed in the vicinity of an electromagnet and continuously exposed to ELF-MF (50 Hz, 0.5 mT) for 7 days. Their behaviour (locomotion, stereotypy, rotations, and immobility) was monitored on days 1, 2, 4, 7, and 14 after reperfusion for 60 min in the open field. It was shown that the 10-min global cerebral ischemia per se induced a significant motor activity increase (locomotion, stereotypy and rotations), and consequently immobility decrease until day 4 after reperfusion, compared to control gerbils. Exposure to ELF-MF inhibited development of ischemia-induced motor hyperactivity during the whole period of registration, but significantly in the first 2 days after reperfusion, when the postischemic hyperactivity was most evident. Motor activity of these gerbils was still significantly increased compared to control ones, but only on day 1 after reperfusion. Our results revealed that the applied ELF-MF (50 Hz, 0.5 mT) decreased motor hyperactivity induced by the 10-min global cerebral ischemia, via modulation of the processes that underlie this behavioural response.
Ključne reči:
Ischemia; 50 Hz magnetic field; Locomotion; Stereotypy; Rotations; Immobility; GerbilsIzvor:
Behavioural Brain Research, 2012, 228, 2, 241-246Finansiranje / projekti:
- Uticaj magnetnih polja i drugih sredinskih stresora na fiziološke odgovore i ponašanje različitih vrsta (RS-MESTD-Basic Research (BR or ON)-173027)
- MMA Grant (VMA/06-10/B.4)
DOI: 10.1016/j.bbr.2011.10.046
ISSN: 0166-4328
PubMed: 22119248
WoS: 000301318900001
Scopus: 2-s2.0-84856223297
URI
https://www.sciencedirect.com/science/article/pii/S0166432811007790?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3801