Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity
2001
Аутори:
Drulović, JelenaDujmović, Irena
Mesaroš, Šarlota
Samardžić, Tatjana
Maksimović-Ivanić, Danijela
Stojsavljević, Nebojša
Lević, Zvonimir
Mostarica Stojković, Marija
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2001 Arnold
Метаподаци
Приказ свих података о документуАпстракт:
A growing body of evidence implicates excessive generation of nitric oxide (NO) within the central nervous system (CNS) in multiple sclerosis (MS). The aim of our study is to analyse nitrite and nitrate as end products of NO in the cerebrospinal fluid (CSF) from MS patients and correlate the concentrations with clinicol characteristics of the disease. CSF nitrite and nitrate concentrations were measured after reduction of nitrate, by Griess reaction, in 105 MS potients, 27 patients with non-inflammatory neurological disorders (NIND) and 13 individuals without neurological disorder (Co). Mean CSF nitrite and nitrate concentrations were significantly higher in patients with MS and NIND compared with the Co patients (9.44 and 8.68, respectively, versus 6.85 microM; P=0.0001 and P=0.031, respectively). There was no significant correlation between CSF nitrite and nitrate concentrations and activity, phase, severity and duration of MS. Our data are in agreement with the results of previous studies which have demonstrated raised concentrations of CSF NO metabolites in MS patients, providing further evidence for NO involvement in MS. The lack of correlation between NO metabolites and disease activity speaks in favour of the possible dual role of NO, as both immunoregulatory and pro-inflammatory molecule, in the pathogenesis of MS.
Кључне речи:
Multiple sclerosis; Nitric oxide; Cerebrospinal fluid; Magnetic resonance imaging; Disease activity; Brain tumourИзвор:
Multiple Sclerosis Journal, 2001, 7, 1, 19-22
DOI: 10.1177/135245850100700104
ISSN: 1352-458
PubMed: 11321188