Reduction of anxiety-like and depression-like behaviors in rats after one month of drinking Aronia melanocarpa berry juice
2016
Autori:
Tomić, MirkoIgnjatović, Đurđica
Tovilović-Kovačević, Gordana
Krstić Milošević, Dijana
Ranković, Slavica
Popović, Tamara
Glibetić, Marija
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© The Royal Society of Chemistry 2016
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The treatment of mood and anxiety disorders by nutraceuticals is gaining growing awareness. Berries of
Aronia melanocarpa (Black chokeberry) and their extracts, exceptionally abundant in diverse phenolic
compounds, have become famous for the highest in vitro antioxidant activity among fruits and notable
health benefits (e.g. anti-diabetic, anti-inflammatory, cardioprotective). This study was designed to investigate
the behavioral effects of month-long unlimited consumption of Aronia master juice (AJ) and/or juice
reconstruct without polyphenols (RJ), in young male rats. AJ was initially evaluated for its content of phenolic
compounds by spectrophotometric assays and HPLC-DAD. Rats that were supplied with three
various water concentrations of AJ and RJ, respectively: 20% + 0% (ARO group), 5% + 15% (RAJ) and 0 +
20% (PLC), were compared with those which consumed only water (CTL). Daily drinking of AJ solution
was significantly elevated from the second or third week onward, which was most expressed in the ARO
group. Only this group displayed behavioral variations, manifested by certain hyperactivity in open field
tests and prominent reductions of anxiety-like behaviors in the elevated plus maze. The ARO rats also
expressed an alleviation of depression-like behavior in forced swimming tests. These findings demonstrate
the beneficial behavioral effects of the one-month-long free drinking of phenolic-rich AJ in rats (>20 ml
per kg b. mass daily) that may be recognized as stimulating, anxiolytic-like and antidepressant-like. The
in vitro assays suggested that MAO-A/MAO-B inhibitions by the phenolic compounds of AJ might be the
possible in vivo mechanisms for such behavioral actions.
Napomena:
Related to: https://radar.ibiss.bg.ac.rs/handle/123456789/3893.
Ključne reči:
Black chokeberry; total phenolic content; anxiety-like behaviors; depression-like behaviorsIzvor:
Food & Function, 2016, 7, 3111-3120Finansiranje / projekti:
- Biološki mehanizmi, nutritivni unos i status polinezasićenih masnih kiselina i folata: Unapređenje ishrane u Srbiji (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.1039/c6fo00321d
ISSN: 2042-6496
PubMed: 27273205