Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases
2020
Authors:
Xie, KanKapetanou, Marianna
Sidiropoulou, Kyriaki
Bano, Daniele
Gonos, Efstathios S.
Mladenović, Aleksandra
Ehninger, Dan
Document Type:
Article (Published version)
,
© 2020 Elsevier B.V.
Metadata
Show full item recordAbstract:
Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.
Keywords:
Aging; Brain; Dietary energy restriction; Metabolism; NeurodegenerationSource:
Mechanisms of Ageing and Development, 2020, 192, 111364-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Helmholtz Future Topic AMPro (Aging and Metabolic Programming)
DOI: 10.1016/j.mad.2020.111364
ISSN: 0047-6374
PubMed: 32991920