The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population
2020
Autori:
Matić Petrović, SanjaNikolić, Nađa
Toljić, Boško
Arambašić Jovanović, Jelena
Miličić, Biljana
Miličić, Tanja
Jotić, Aleksandra
Vidaković, Melita
Milašin, Jelena
Pucar, Ana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2020 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between −308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed. Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA). Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037−0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35−7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954−0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D. Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D.
Ključne reči:
Periodontitis; Single nucleotide polymorphisms; Tumor necrosis factor - alpha; Tumor necrosis factor receptors; Type 2 diabetes mellitusIzvor:
Archives of Oral Biology, 2020, 120, 104929-Finansiranje / projekti:
- Interakcija etiopatogenetskih mehanizama parodontopatije i paeriimplantitisa sa sistemskim bolestima današnjice (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
- Genetička kontrola i molekularni mehanizmi u malignim, inflamatornim i razvojnim patologijama orofacijalne regije (RS-MESTD-Basic Research (BR or ON)-175075)
DOI: 10.1016/j.archoralbio.2020.104929
ISSN: 0003-9969
PubMed: 33091664
WoS: 000588270000009
Scopus: 2-s2.0-85092640281
Institucija/grupa
IBISSAPA:
Matic Petrovic, S., Nikolic, N., Toljic, B., Arambasic-Jovanovic, J., Milicic, B., Milicic, T., et al. (2020). The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. Archives of Oral Biology, 120, 104929.Vancouver:
Matic Petrovic S, Nikolic N, Toljic B, Arambasic-Jovanovic J, Milicic B, Milicic T, Jotic A, Vidakovic M, Milasin J, Pucar A. The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. Arch Oral Biol. 2020;120:104929.Related items
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