dc.creator | Đurašević, Siniša | |
dc.creator | Stojković, Maja | |
dc.creator | Sopta, Jelena | |
dc.creator | Pavlović, Slađan | |
dc.creator | Borković Mitić, Slavica | |
dc.creator | Ivanović, Anđelija | |
dc.creator | Jasnić, Nebojša | |
dc.creator | Tosti, Tomislav | |
dc.creator | Đurović, Saša | |
dc.creator | Đorđević, Jelena | |
dc.creator | Todorović, Zoran | |
dc.date.accessioned | 2021-01-15T10:04:00Z | |
dc.date.available | 2021-01-15T10:04:00Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4090 | |
dc.description.abstract | Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium
is an anti‑ischemic agent that shifts energy production from fatty acid oxidation to less oxygen‑
consuming glycolysis. Thus, we investigated the effects of a 4‑week meldonium pre‑treatment
(300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that
meldonium ameliorates I/R‑induced liver inflammation and injury, as confirmed by liver histology,
and by attenuation of serum alanine‑ and aspartate aminotransferase activity, serum and liver
high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and
the phosphorylated nuclear factor kappa‑light‑chain‑enhancer of activated B cells. Through the
increased hepatic activation of the nuclear factor erythroid 2‑related factor 2, meldonium improves
the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum
and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione
and free thiol groups content, and hepatic copper‑zinc superoxide dismutase, manganese superoxide
dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results,
it can be concluded that meldonium represent a protective agent against I/R‑induced liver injury, with
a clinical significance in surgical procedures. | sr |
dc.language.iso | en | sr |
dc.publisher | Nature Publishing Group | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200051/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | sr |
dc.subject | Ischemia/reperfusion | sr |
dc.subject | Liver | sr |
dc.subject | Meldonium | sr |
dc.subject | Inflammation | sr |
dc.subject | Oxidative stress | sr |
dc.subject | Rats | sr |
dc.title | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Јаснић, Небојша; Тости, Томислав; Ђуровић, Саша; Ђорђевић, Јелена; Тодоровић, Зоран; Ђурашевић, Синиша; Стојковић, Маја; Сопта, Јелена; Павловић, Слађан; Борковић-Митић, Славица; Ивановић, Aнђелија; | |
dc.rights.holder | © The Author(s) 2021 | sr |
dc.citation.issue | 1 | |
dc.citation.volume | 11 | |
dc.identifier.doi | 10.1038/s41598-020-80011-y | |
dc.identifier.scopus | 2-s2.0-85099371879 | |
dc.identifier.wos | 000626774100019 | |
dc.citation.apa | Đurašević, S., Stojković, M., Sopta, J., Pavlović, S., Borković-Mitić, S., Ivanović, A., et al. (2021). The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. Scientific Reports, 11(1), 1305. | |
dc.citation.vancouver | Đurašević S, Stojković M, Sopta J, Pavlović S, Borković-Mitić S, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović Z. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. Sci Rep. 2021;11(1):1305. | |
dc.citation.spage | 1305 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/8052/bitstream_8052.pdf | |
dc.citation.rank | M21 | |