Variation of the Cytokine Profiles in Gingival Crevicular Fluid Between Different Groups of Periodontally Healthy Teeth
Varijacija profila citokina u gingivalnoj zglobnoj tečnosti između različitih grupa parodontalno zdravih zuba
2020
Authors:
Taso, ErvinRakić, Mia
Stefanović, Vladimir
Petković-Ćurčin, Aleksandra
Stanojević, Ivan
Đukić, Mirjana
Struillou, Xavier
Vojvodić, Danilo
Banović, Tatjana
Kanjevac, Tatjana
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Profiling of biomarkers of physiological process represents an integrative part in optimisation of diagnostic markers in order to adjust the diagnostic ranges to the potential effects of the local factors such occlusal forces in case of periodontal tissues. The objective of this study was estimation of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12, IL-13, IL-17, IL-22, TNFα and IFNγ concentrations in gingival crevicular fluid samples (GCF) between different groups of teeth. Two hundred fifty-nine systemically healthy non-smokers having at least one vital tooth without restorations, with healthy periodontal tissues, were clinically examined and the GCF sample was retrieved. The cytokine levels were estimated using flow cytometry and compared between central incisors (CI), lateral incisors, canines, first premolars, second premo-lars, first molars and second molars. Cytokine profiles varied between different groups of teeth with tendency of increase in pro-inflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context. Cytokine profiles varied between different groups of teeth with tendency of increase in pro-inflammatory cytokines from anterior teeth toward molars. Molars might be considered teeth with natural predisposition for faster bone resorption while the adjustment of diagnostic range of periodontal biomarkers for anterior or posterior teeth should be considered within diagnostic context.
Keywords:
Biomarkers; Cytokines; Gingival crevicular fluid; Occlusal forces; Periodontalni ligament; Periodontal disease; Periodontal ligamentSource:
Serbian Journal of Experimental and Clinical Research, 2020, 21, 4, 333-341Funding / projects:
- Brain plasticity in aging: effect of dietary restriction and anesthesia (RS-MESTD-Basic Research (BR or ON)-173056)
- Interraction of etiopathogenetic mechanisms of periodontal disease and periimplantitis with the systemic disorders of the present day (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
URI
https://content.sciendo.com/doi/10.2478/sjecr-2019-0015https://radar.ibiss.bg.ac.rs/handle/123456789/4167