Virome/SARS-CoV-2 cross-talk: Free space for natural products
Virom/SARS-CoV2 interakcija: Upražnjeno mesto za prirodne komponente
2020
Document Type:
Article (Published version)
,
© 2020 by the Nutrition Society
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Show full item recordAbstract:
One of the most striking marks of infection caused by the SARS-CoV-2
is the distinguishing heterogeneity of the clinical presentations in a
population that varies from asymptomatic to severe forms. Pandemic
proportion brings into the foreground the number of people with severe
forms of the disease, putting aside the fact that a large portion of the
population is asymptomatic, making them silent carriers of the virus. Additional confusion is made by inconsistent data about the presence of the virus in the nasopharyngeal region and the manifestation
of the disease symptoms. Different tissue distribution of virus in the
body starting from guts, liver, muscles, kidney, etc. without any signs of
tissue destruction, opens up the possibility that individuals with negative results of PCR test in the nasopharyngeal swab may also be latent
carriers of the infection. Overall clinical presentation of the disease is
influenced by the initial protection gained through the accumulated
“experience” collected from the previous encountering of corona family and
noncorona viruses, resulting in overlapping of the humoral and cellular
immunity. Apart from this, an unjustifiably neglected but very significant
form of host defense against infection is disease tolerance based on cohabitation with the pathogen. It is important to note that consequences of
the disease tolerance in terms of pathological and epidemiological aspects are quite different then classical antiviral immune response. This
work will elaborate the impact of virome on the course of infection at all
stages taking into account both immune resistance, as an ability of the
host immune system to eliminate the pathogen, and disease tolerance, as
a form of host defense with neutral to positive impact to pathogen load.
Also, in accordance with the above mentioned, the potential of naturally occurring compounds to profile the course of infection and to support
currently available protocols for COVID-19 treatment was discussed
Keywords:
SARS-CoV-2; Disease tolerance; Virome; Immune resistance; Naturally occurring compoundsSource:
Hrana i ishrana, 2020, 61, 1, 25-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/4168http://hrana-ishrana.org/wp-content/uploads/2021/03/Broj-2-Vol-61-2020.pdf