Protective effects of pumpkin (Cucurbita pepo L.) seed oil on rat liver damage induced by chronic alcohol consumption
2021
Аутори:
Radić, IvanMirić, Mirjana
Mijović, Milica
Tatalović, Nikola
Mitić, Miloš
Nestorović, Vojkan
Adžić, Miroslav
Blagojević, Duško
Popović, Ljiljana
Janićijević Hudomal, Snežana
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Pumpkin seed oil (PSO) possesses a protective potential against liver injury due to the presence of biologically active ingredients. Adult male albino rats were administrated PSO (per os, 2 mL/kg b.w./day) and a 12% ethanol solution in water, ad libitum, with an average intake of 8.14 g of ethanol/kg bw/day for 6 weeks. Congestion, hepatic central vein dila-tion, portal vein branch dilation, Kupffer cell hyperplasia, fatty liver changes, hepatocyte focal necrosis were observed after daily alcohol intake. All observed changes were reduced when PSO was ingested with ethanol. PSO intake itself induced discrete cellular edema, congestion and slight dilatation of the central and portal vain branches. Chronic ethanol intake elevated catalase (CAT) activity and glutathione reductase (GR) protein expression; concomitant PSO intake had no effect on CAT activity or GR protein expression. PSO intake decreased the activities of GR, glutathione-S-transferase (GST) and xanthine oxidase (XOD) in the liver, probably due to the ingestion of antioxidants. Intake of PSO and ethanol significantly decreased cytosolic superoxide dismutase (SOD1) and increased NF-κB protein expression compared to ethanol intake, suggesting that the protective effects of PSO were mediated by the NF-κB signaling pathway. Our results reveal a therapeutic potential of PSO in alcoholic liver disease.
Кључне речи:
Chronic alcohol consumption; Alcoholic liver disease; Pumpkin seed oil; Antioxidant enzymes; NF-κBИзвор:
Archives of Biological Sciences, 2021, 73, 1, 123-133Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Повезане информације:
- Повезани садржај
https://radar.ibiss.bg.ac.rs/handle/123456789/4182
DOI: 10.2298/ABS201205008R
ISSN: 0354-4664
WoS: 000631279700013
Scopus: 2-s2.0-85103509931
URI
http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6170https://radar.ibiss.bg.ac.rs/handle/123456789/4181