Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
2021
Authors:
Aničić, NedaGašić, Uroš
Lu, Feng
Ćirić, Ana
Ivanov, Marija
Jevtić, Bojan
Dimitrijević, Milena
Anđelković, Boban
Skorić, Marijana
Nestorović Živković, Jasmina
Mao, Yingle
Liu, Jia
Tang, Chunping
Soković, Marina
Ye, Yang
Mišić, Danijela
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,transNL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
Keywords:
1; 5; 9-epideoxyloganic acid; Nepeta; Antibiofilm; Antimicrobial activity; Immunomodulatory effects; NepetalactoneSource:
Pharmaceuticals, 2021, 14, 5, 414-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/ph14050414
ISSN: 1424-8247
PubMed: 33925239