dc.creator | Shirif, Abdulbaset Zidane | |
dc.creator | Kovačević, Sanja | |
dc.creator | Brkljačić, Jelena | |
dc.creator | Teofilović, Ana | |
dc.creator | Elaković, Ivana | |
dc.creator | Đorđević, Ana | |
dc.creator | Matić, Gordana | |
dc.date.accessioned | 2021-07-20T12:13:00Z | |
dc.date.available | 2021-07-20T12:13:00Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4259 | |
dc.description.abstract | The modern lifestyle brings both excessive fructose consumption and daily exposure
to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important
points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy
homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-
week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated
potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation.
The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated
receptors- and - and stimulated lipid uptake, lipolysis and -oxidation in the muscle of fructosefed
stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by
lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin
receptor supstrate-1 and Akt, as well as the level of 11 -hydroxysteroid dehydrogenase type 1
and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B,
nuclear factor- B, tumor necrosis factor- , were observed in the muscle of fructose-fed stressed rats.
Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle
can make a setting for lipid-induced inflammation and the development of insulin resistance in
fructose-fed stressed rats. | sr |
dc.language.iso | en | sr |
dc.publisher | Basel, Switzerland: MDPI | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.relation | Swiss National Science Foundation, Grant SCOPES JRP IZ73Z0_152331 | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences, Special Issue Glucocorticoids and Metabolic Disorders | sr |
dc.subject | fructose | sr |
dc.subject | chronic stress | sr |
dc.subject | skeletal muscle | sr |
dc.subject | glucocorticoids | sr |
dc.subject | insulin | sr |
dc.subject | lipid metabolism | sr |
dc.title | Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Елаковић, Ивана; Ђорђевић, Aна; Теофиловић, Aна; Матић, Гордана; Схириф, Aбдулбасет Зидане; Ковачевић, Сања; Бркљачић, Јелена; | |
dc.rights.holder | © 2021 the authors | sr |
dc.citation.issue | 13 | |
dc.citation.volume | 22 | |
dc.identifier.doi | 10.3390/ijms22137206 | |
dc.identifier.scopus | 2-s2.0-85108973513 | |
dc.identifier.wos | 000671173200001 | |
dc.citation.apa | Shirif, A. Z., Kovačević, S., Brkljačić, J., Teofilović, A., Elaković, I., Djordjevic, A., et al. (2021). Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress. International Journal of Molecular Sciences, 22(13), 7206. | |
dc.citation.vancouver | Shirif AZ, Kovačević S, Brkljačić J, Teofilović A, Elaković I, Djordjevic A, Matić G. Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress. Int J Mol Sci. 2021;22(13):7206. | |
dc.citation.spage | 7206 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/8569/ijms-22-07206.pdf | |
dc.citation.rank | M21 | |