Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications
2021
Autori:
Ristić, BiljanaHarhaji-Trajković, Ljubica
Bošnjak, Mihajlo
Dakić, Ivana
Mijatović, Srđan
Trajković, Vladimir
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Graphene-based nanomaterials (GNM) are plausible candidates for cancer therapeutics
and drug delivery systems. Pure graphene and graphene oxide nanoparticles, as well as graphene
quantum dots and graphene nanofibers, were all able to trigger autophagy in cancer cells through both
transcriptional and post-transcriptional mechanisms involving oxidative/endoplasmic reticulum
stress, AMP-activated protein kinase, mechanistic target of rapamycin, mitogen-activated protein
kinase, and Toll-like receptor signaling. This was often coupled with lysosomal dysfunction and
subsequent blockade of autophagic flux, which additionally increased the accumulation of autophagy
mediators that participated in apoptotic, necrotic, or necroptotic death of cancer cells and influenced
the immune response against the tumor. In this review, we analyze molecular mechanisms and
structure–activity relationships of GNM-mediated autophagy modulation, its consequences for
cancer cell survival/death and anti-tumor immune response, and the possible implications for the
use of GNM in cancer therapy.
Ključne reči:
graphene; nanomaterial; cancer; autophagy; apoptosis; necrosisIzvor:
Cancers, 2021, 13, 16, 4145-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200110 (Univerzitet u Beogradu, Medicinski fakultet) (RS-MESTD-inst-2020-200110)
DOI: 10.3390/cancers13164145
ISSN: 2072-6694
PubMed: 34439299