Sepsis and multiple sclerosis: Causative links and outcomes
2021
Authors:
Miljković, ĐorđeStanisavljević, Suzana
Jensen, Isaac J
Griffith, Thomas S
Badovinac, Vladimir P
Document Type:
Article (Published version)
,
© 2021 European Federation of Immunological Societies. Published by Elsevier B.V.
Metadata
Show full item recordAbstract:
Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.
Keywords:
Gut microbiota; Multiple sclerosis; SepsisSource:
Immunology Letters, 2021, 238, 40-46Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program 6409283
- United States Department of Health & Human Services National Institutes of Health (NIH) - USA
- Veterans Health Administration Merit Review Award I01BX001324
DOI: 10.1016/j.imlet.2021.07.008
ISSN: 0165-2478
PubMed: 34320384
WoS: 000691308300005
Scopus: 2-s2.0-85111561634
URI
https://linkinghub.elsevier.com/retrieve/pii/S0165247821001176https://radar.ibiss.bg.ac.rs/handle/123456789/4455