Agmatine reduces chlorpromazine prooxidant effects in rat hippocampus and striatum
2021
Autori:
Dejanović, BratislavBegović-Kuprešanin, Vesna
Stevanović, Ivana
Lavrnja, Irena
Šošić-Jurjević, Branka
Ninković, Milica
Trifunović, Svetlana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The use of the antidepressant drug chlorpromazine (CPZ) is linked to the occurrence of oxidative stress in some brain structures. Thus, overcoming the side effects of CPZ is of great importance. Because agmatine (AGM) can act as a free radical scavenger, it is an interesting compound as an adjunct to CPZ therapy. The aim of our study was to investigate the enzymatic parameters of oxidative stress in the hippocampus and striatum of rats after CPZ treatment, and the potential protective effects of AGM. Rats were injected as follows with (i) 1 mL/kg b.w. saline; (ii) a single intraperitoneal (i.p.) dose of CPZ (38.7 mg/kg); (iii) CPZ (38.7 mg/kg) and AGM (75 mg/kg); (iv) AGM (75 mg/kg). CPZ induced an increase in superoxide anion radical (O2 catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), were lowered in both the hippocampus striatum. Cotreatment with CPZ and AGM protected the examined brain structures by reversing the antioxidant enzyme control values. Following CPZ treatment, the effects were more pronounced for SOD and GPx in the hippocampus, the striatum. The full effect of restored superoxide production was achieved in the striatum, which points to the role of CAT. The obtained results suggest that CPZ in combination with AGM may be considered as a new treatment strategy.
Ključne reči:
Agmatine; Chlorpromazine; Hippocampus; Oxidative stress; StriatumIzvor:
Archives of Biological Sciences, 2021, 73, 3, 353-359Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Medical Faculty of Military Medical Academy University of Defense MFVMA/04/19-21
DOI: 10.2298/abs210429028d
ISSN: 0354-4664
WoS: 000713637400004
Scopus: 2-s2.0-85117943371
URI
http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46642100028Dhttps://radar.ibiss.bg.ac.rs/handle/123456789/4651
https://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6557