Rosmarinic acid–Modes of antimicrobial and antibiofilm activities of common plant polyphenol
2022
Document Type:
Article (Published version)
,
© 2021 SAAB. Published by Elsevier B.V.
Metadata
Show full item recordAbstract:
Emerging antimicrobial resistance and side effects associated with antibiotics overuse are driving the need for the novel antimicrobial therapeutics with the natural compounds considered as an appealing alternative. Rosmarinic acid is abundantly present in medicinal plants. This study aimed to elucidate its possible role as an inhibitor of planktonic and biofilm microorganism growth, along with its antifungal mechanisms. In this study, rosmarinic acid showed promising anticandidal (MIC 0.1–0.2 mg/mL) and antibacterial (MIC 0.002->0.8 mg/mL) activity. To some extent it was able to prevent cell attachment and eradicate established biofilms. Rosmarinic acid antifungal mechanisms included reduction of mitochondrial activity, alteration in membrane integrity, and slight inhibition of protease production but not binding to ergosterol. Its antibiofilm activity was moderately linked to the reduction in exopolysaccharide production. Considering its wide antimicrobial and antibiofilm spectrum rosmarinic acid could be further explored as an antimicrobial agent along with range of medicinal plants with rosmarinic acid as the dominant compound. Nevertheless, rosmarinic acid could serve as the basis for the development of antimicrobials employing novel mechanisms of activity.
Keywords:
Antibiofilm; Anticandidal; Mode of action; Polyphenolic compound; Rosmarinic acidSource:
South African Journal of Botany, 2022, 146, 521-527Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
Related info:
DOI: 10.1016/j.sajb.2021.11.050
ISSN: 0254-6299
WoS: 00078883640001
Scopus: 2-s2.0-85120878306
URI
https://linkinghub.elsevier.com/retrieve/pii/S025462992100497Xhttp://radar.ibiss.bg.ac.rs/handle/123456789/4745