Ethyl pyruvate, a versatile protector in inflammation and autoimmunity.
2022
Document Type:
Article (Accepted Version)
,
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG
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Show full item recordAbstract:
Ethyl pyruvate (EP) has potent influence on redox processes, cellular metabolism, and inflammation. It has been intensively studied in numerous animal models of systemic and organ-specific disorders whose pathogenesis involves a strong immune component. Here, basic chemical and biological properties of EP are discussed, with an emphasis on its redox and metabolic activity. Further, its influence on myeloid and T cells is considered, as well as on intracellular signaling beyond its effect on immune cells. Also, the effects of EP on animal models of chronic inflammatory and autoimmune disorders are presented. Finally, a possibility to apply EP as a treatment for such diseases in humans is discussed. Scientific papers cited in this review were identified using the PubMed search engine that relies on the MEDLINE database. The reference list covers the most important findings in the field in the past twenty years.
Note:
This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00011-021-01529-z
Keywords:
Autoimmunity; Ethyl pyruvate; Inflammation; Metabolism; RedoxSource:
Inflammation Research, 2022Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
Related info:
DOI: 10.1007/s00011-021-01529-z
ISSN: 1023-3830
PubMed: 34999919
WoS: 000740384000001
Scopus: 2-s2.0-85122693675
URI
https://link.springer.com/10.1007/s00011-021-01529-zhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8742706
http://radar.ibiss.bg.ac.rs/handle/123456789/4766
http://radar.ibiss.bg.ac.rs/handle/123456789/4778