Strain differences in intestinal toxicity of warfarin in rats
2016
Authors:
Mirkov, IvanaPopov Aleksandrov, Aleksandra
Ninkov, Marina
Mileusnić, Dina
Demenesku, Jelena
Zolotarevski, Lidija
Subota, Vesna
Stefik, Debora
Kataranovski, Dragan
Kataranovski, Milena
Document Type:
Article (Accepted Version)
Metadata
Show full item recordAbstract:
Intestinal hemorrhage characterizes effectiveness of warfarin (WF) as rodenticide and is among
adverse effects of therapy in humans. Having in mind genetic variations in the effectiveness of
WF in wild rats and in the doses required for therapeutic effect, strain differences in the intestinal
toxicity of oral warfarin in rats were examined in this study. High WF dose (3.5 mg/l) led to
mortality in Albino Oxford (AO) rats, with no lethality in Dark Agouti (DA) rats. Higher values
of prothrombin time were noted at low WF dose (0.35 mg/l) in the former strain. Leukocyte
infiltration in intestine noted at this dose in both strains was associated with oxidative injury and
more pronounced anti-oxidative response in AO rats. Suppression of mesenteric lymph node cell
proliferation and IFN-γ and IL-10 production in AO rats and lack of these effects in DA rats,
represent different strategies to protect vulnerable intestine from harmful immune responses.
Note:
This is the peer reviewed version of the following article: Mirkov I, Popov Aleksandrov A, Ninkov M, Mileusnic D, Demenesku J, Zolotarevski L, Subota V, Stefik D, Kataranovski D, Kataranovski M. Strain differences in intestinal toxicity of warfarin in rats. Environ Toxicol Pharmacol. 2016;48:175–82. https://doi.org/10.1016/j.etap.2016.10.019
Keywords:
Oral warfarin administration; Albino Oxford (AO) and Dark agouti (DA) rats; Intestinal injury; Mesenteric lymph nodesSource:
Environmental Toxicology and Pharmacology, 2016, 48, 175-182Funding / projects:
- Immunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (RS-MESTD-Basic Research (BR or ON)-173039)
Related info:
DOI: 10.1016/j.etap.2016.10.019
ISSN: 1382-6689
PubMed: 27816002