Strain differences in intestinal toxicity of warfarin in rats
2016
Autori:
Mirkov, IvanaPopov Aleksandrov, Aleksandra
Ninkov, Marina
Mileusnić, Dina
Demenesku, Jelena
Zolotarevski, Lidija
Subota, Vesna
Stefik, Debora
Kataranovski, Dragan
Kataranovski, Milena
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2016 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Intestinal hemorrhage characterizes effectiveness of warfarin (WF) as rodenticide and is amongadverse effects of therapy in humans. Having in mind genetic variations in the effectiveness ofWF in wild rats and in the doses required for therapeutic effect, strain differences in the intestinaltoxicity of oral warfarin in rats were examined in this study. High WF dose (3.5 mg/l) led tomortality in Albino Oxford (AO) rats, with no lethality in Dark Agouti (DA) rats. Higher valuesof prothrombin time were noted at low WF dose (0.35 mg/l) in the former strain. Leukocyteinfiltration in intestine noted at this dose in both strains was associated with oxidative injury andmore pronounced anti-oxidative response in AO rats. Suppression of mesenteric lymph node cellproliferation and IFN-γ and IL-10 production in AO rats and lack of these effects in DA rats,represent different strategies to protect vulnerable intestine from harmful immune responses.
Ključne reči:
Oral warfarin administration; Albino Oxford (AO) and Dark agouti (DA) rats; Intestinal injury; Mesenteric lymph nodesIzvor:
Environmental Toxicology and Pharmacology, 2016, 48, 175-182Finansiranje / projekti:
- Imunomodulatorni efekti ksenobiotika i biotičkih faktora životne sredine na populacije mišolikih glodara (RS-MESTD-Basic Research (BR or ON)-173039)
Povezane informacije:
- Druga verzija
https://radar.ibiss.bg.ac.rs/handle/123456789/4812
DOI: 10.1016/j.etap.2016.10.019
ISSN: 1382-6689
PubMed: 27816002