Late-Onset Calorie Restriction Improves Lipid Metabolism and Aggravates Inflammation in the Liver of Old Wistar Rats.
2022
Autori:
Teofilović, AnaVratarić, Miloš
Veličković, Nataša
Vojnović-Milutinović, Danijela
Mladenović, Aleksandra
Prvulović, Milica
Đorđević, Ana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2022 Teofilović, Vratarić, Veličković, Vojnović Milutinović, Mladenovic, Prvulovic and Djordjevic
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Aging is a progressive process that could disturb metabolic homeostasis in the liver via ectopic lipid accumulation, oxidative stress, and deterioration of inflammatory response. Although calorie restriction (CR) is recognized as beneficial for life span and health span prolongation, it is still unclear how late-onset CR, characterized by late beginning and short duration, affects age-related processes. The aim of this study was to examine how late-onset CR-induced metabolic adjustments impact lipid status and inflammation in the liver of old rats. The experiments were conducted on aging male Wistar rats fed ad libitum (AL) or exposed to late-onset CR (60% of AL daily intake) from 21st to 24th month. The results showed that late-onset CR reduces body weight, visceral adipose tissue and liver mass, and triglyceride levels when compared to old animals on AL diet. The ameliorating effects of CR on lipid metabolism include increased activity of AMP-activated protein kinase, suppressed de novo fatty acid synthesis, stimulated β-oxidation, decreased lipotoxicity, and limited triglyceride synthesis and packaging in the liver. Restricted diet regime, however, does not improve expression of antioxidant enzymes, although it leads to progression of age-related inflammation in the liver, partially through lower corticosterone concentration and decreased activation of glucocorticoid receptor. In conclusion, late-onset CR is able to restore age-related imbalance of lipid metabolism in the liver, but has a negative impact on hepatic inflammatory status, implying that the type of diet for older individuals must be balanced and chosen carefully with appropriate duration and start point.
Ključne reči:
Aging; Calorie restriction; Inflammation; Lipid metabolism; LiverIzvor:
Frontiers in Nutrition, 2022, 9, 899255-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3389/fnut.2022.899255
ISSN: 2296-861X
PubMed: 35677539
WoS: 000806852000001
[ Google Scholar ]URI
https://www.frontiersin.org/articles/10.3389/fnut.2022.899255/fullhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9168317
http://radar.ibiss.bg.ac.rs/handle/123456789/5004