Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome
2022
Authors:
Zavišić, GordanaRistić, Slavica
Rikalović, Milena
Petković, Branka
Janković, Drina
Vukadinović, Aleksandar
Petričević, Saša
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome. © 2022
Keywords:
Biochemical parameters; Lactobacillus spp; Metabolic syndromeSource:
Journal of Functional Foods, 2022, 95, 105167-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
DOI: 10.1016/j.jff.2022.105167
ISSN: 1756-4646
WoS: 000863764500004
Scopus: 2-s2.0-85134990526
URI
https://linkinghub.elsevier.com/retrieve/pii/S1756464622002377http://radar.ibiss.bg.ac.rs/handle/123456789/5091