An in vitro study of the Origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: antibacterial, antibiofilm, antioxidant, and cytotoxic activities
2022
Authors:
Kostić, MarinaIvanov, Marija
Marković, Tatjana
Sanković Babić, Snežana
Barros, Lillian
Calhelha, Ricardo
Soković, Marina
Ćirić, Ana
Document Type:
Article (Published version)
,
© 2022 by the Taylor & Francis
Metadata
Show full item recordAbstract:
The chemical composition and biological activity of essential oils (EOs) from leaves of Origanum minutiflorum O. Schwarz & P.H.Davis, and seeds of Coriandrum sativum L. were investigated. Chemical analyses of EOs were performed and the major components were carvacrol (81.5%) and linalool (69.6%), respectively. The antimicrobial activity was assessed against several bacteria originating from the tonsillar tissue. Activities of EOs against Staphylococcus aureus biofilm were investigated, as well as the effect of the mixture of these EOs and antibiotics against the pathogen. The antioxidant activity of both EOs was determined by TBARS assay, and examined wild oregano EO showed better activity. Also, cytotoxicity of EOs was evaluated in vitro and both EOs showed potential to inhibit further proliferation of tumor cells. This study reported for the first time the effects of EOs on chronic tonsillitis causative pathogens, supporting their role as a natural bioactive therapeutic agent with possible antimicrobial applications.
Keywords:
Coriander seed oil; Cytotoxicity; Infections; Staphylococcus aureus; Wild oregano leaf oilSource:
Journal of Essential Oil Research, 2022, 34, 6, 533-543Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Foundation for Science and Technology (FCT, Portugal)
DOI: 10.1080/10412905.2022.2107103
ISSN: 1041-2905
WoS: 000836954300001
Scopus: 2-s2.0-85135524793
URI
https://www.tandfonline.com/doi/full/10.1080/10412905.2022.2107103http://radar.ibiss.bg.ac.rs/handle/123456789/5101