The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice
2022
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Authors:
Jovanović Macura, IrenaĐuričić, Ivana
Major, Tamara
Milanović, Desanka
Brkić, Marjana
Šobajić, Slađana
Kanazir, Selma
Ivković, Sanja
Document Type:
Article (Published version)
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Show full item recordAbstract:
The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.
Keywords:
DHA; EPA; Fish oil; Mfsd2a; Retina; RPESource:
Journal of Functional Foods, 2022, 99, 105302-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
DOI: 10.1016/j.jff.2022.105302
ISSN: 1756-4646
WoS: 000891841200010
Scopus: 2-s2.0-85140635058
URI
https://linkinghub.elsevier.com/retrieve/pii/S1756464622003723http://radar.ibiss.bg.ac.rs/handle/123456789/5174