Phenethyl Ester of Gallic Acid Ameliorates Experimental Autoimmune Encephalomyelitis
2022
Authors:
Stegnjaić, GoranTsiailanis, Antonios D.
Lazarević, Milica
Gkalpinos, Vasileios K.
Nikolovski, Neda
Antoniou, Thomas
Stanisavljević, Suzana
Dimitrijević, Mirjana
Momčilović, Miljana
Miljković, Đorđe
Tzakos, Andreas G.
Jevtić, Bojan
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Gallic acid is a phenolic acid present in various plants, nuts, and fruits. It is well known for
its anti-oxidative and anti-inflammatory properties. The phenethyl ester of gallic acid (PEGA) was
synthesized with the aim of increasing the bioavailability of gallic acid, and thus its pharmacological
potential. Here, the effects of PEGA on encephalitogenic cells were examined, and PEGA was
found to modulate the inflammatory activities of T cells and macrophages/microglia. Specifically,
PEGA reduced the release of interleukin (IL)-17 and interferon (IFN)-γ from T cells, as well as NO,
and IL-6 from macrophages/microglia. Importantly, PEGA ameliorated experimental autoimmune
encephalomyelitis, an animal model of chronic inflammatory disease of the central nervous system
(CNS)—multiple sclerosis. Thus, PEGA is a potent anti-inflammatory compound with a perspective
to be further explored in the context of CNS autoimmunity and other chronic inflammatory disorders.
Keywords:
experimental autoimmune encephalomyelitis; T cells; macrophages; microglia; cytokinesSource:
Molecules, 2022, 27, 24, 8770-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)