Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis
2022
Authors:
Nikolić-Kokić, AleksandraTatalović, Nikola
Brkljačić, Jelena
Mijović, Milica
Nestorović, Vojkan
Mijušković, Ana
Oreščanin-Dušić, Zorana
Vidonja Uzelac, Teodora
Nikolić, Milan
Spasić, Snežana
Blagojević, Duško
Miljević, Čedo
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Sexual dysfunction, as a noticeable adverse effect of atypical antipsychotic drugs (APDs) for the treatment of schizophrenia, has not been investigated in detail. A study was undertaken to investigate whether 28-day long treatment with clozapine, ziprasidone or sertindole (using a recommended daily dose for atypical antipsychotic therapy), induced histopathological changes both in rat testicles and prostate, changed the activity of the antioxidant defence system and altered blood testosterone and prolactin. Clozapine, ziprasidone and sertindole induced histopathological changes in rat testicular tissue, which could be attributed to a disturbed testicular antioxidant defence system in addition to an altered prolactin to testosterone ratio. None of the APD treatments induced histopathological changes in prostate. Our results demonstrate that APDs have the capacity to change both redox and endocrinological balance. One or both outcomes could underline testicular degeneration and disturbed spermatogenesis.
Keywords:
antioxidant enzymes; atypical antipsychotics; prostate; testiclesSource:
International Journal of Molecular Sciences, 2022, 23, 22, 13698-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/ijms232213698
ISSN: 1422-0067
PubMed: 36430171