Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems
2023
Authors:
Radovanović, MarinaKekić, Dusan
Gajić, Ina
Kabić, Jovana
Jovićević, Miloš
Kekić, Natalija
Opavski, Nataša
Ranin, Lazar
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Antimicrobial resistance (AMR) poses a substantial threat to human health. The commensal bacteria of the gut microbiome were shown to serve as a reservoir of antibiotic resistance genes (ARGs), termed the gut resistome, which has the potential to transfer horizontally to pathogens and contribute to the emergence of drug-resistant bacteria. Namely, AMR traits are generally linked with mobile genetic elements (MGEs), which apart from disseminating vertically to the progeny, may cross horizontally to the distantly related microbial species. On the other hand, while probiotics are generally considered beneficiary to human health, and are therefore widely consumed in recent years most commonly in conjunction with antibiotics, the complexities and extent of their impact on the gut microbiome and resistome have not been elucidated. By reviewing the latest studies on ARG containing commercial probiotic products and common probiotic supplement species with their actual effects on the human gut resistome, this study aims to demonstrate that their contribution to the spread of ARGs along the GI tract merits additional attention, but also indicates the changes in sampling and profiling of the gut microbiome which may allow for the more comprehensive studying of the effects of probiotics in this part of the resistome.
Keywords:
antimicrobial resistance (AMR) genes; gut microbiome; gut resistome; mobile genetic elements (MGEs); probiotic bacteriaSource:
Frontiers in Nutrition, 2023, 10, 1054555-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Antibiotic resistant bacterial pathogens in Serbia: phenotypic and genotypic characterization (RS-MESTD-Basic Research (BR or ON)-175039)
DOI: 10.3389/fnut.2023.1054555
ISSN: 2296-861X
PubMed: 36819705
Scopus: 2-s2.0-85148364216
URI
https://www.frontiersin.org/articles/10.3389/fnut.2023.1054555/fullhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9928729
http://radar.ibiss.bg.ac.rs/handle/123456789/5486