Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy
2018
Authors:
Savić, DanijelaOpačić, Miloš
Ristić, Aleksandar
Sokić, Dragoslav
Baščarević, Vladimir
Raičević, Savo
Savić, Slobodan
Živin, Marko
Šelih, Vid Simon
Spasić, Snežana
Spasojević, Ivan
Contributors
Spasojević, IvanDocument Type:
Conference object (Published version)
,
© 2018 by the Faculty of Chemistry
Metadata
Show full item recordAbstract:
The accumulating evidence on the relation between the disturbed metal homeostasis
and epilepsy urges the need for data regarding the total metal concentrations, as well
as metal distribution in the brain itself, in order to indicate where to direct the
potential therapy, to metal supplementation or chelation. This paper summarizes our
results on the measurements of some important essential metals in hippocampi of
patients with mesial temporal lobe epilepsy (mTLE) who underwent
amigdalohippocampectomy. The key findings point out that levels of copper and
manganese are deficient in hippocampi of mTLE patients, and that their
concentrations correlated positively with neuronal loss in affected regions of sclerotic
hippocampus. In addition, the Cu concentration was decreased in the areas of total
neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor
deficient compared to control. Our results contribute to deeper insight of metals
biology in the epilepsy and may represent the initial point of new and non-invasive
therapy of drug resistant epilepsy.
Funding / projects:
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
- Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-MESTD-Basic Research (BR or ON)-173014)
- Slovenian Research Agency (ARRS), Project numbers P3-0171 and P1-0034.
In:
- Spasojević I, editor. Proceedings: Serbian Biochemical Society Eigth Conference with international participation: Coordination in Biochemistry and Life; 2018 Nov 16; Novi Sad, Serbia. Belgrade : Faculty of Chemistry : Serbian Biochemical Society; 2018. p. 105-12.