Antioxidant defense enzyme activities in the interscapular brown adipose tissue of rats treated with cadmium and coenzyme Q10
2003
Autori:
Pavlović, SlađanOgnjanović, Branka
Štajn, Andraš Š.
Žikić, Radoslav V.
Saičić, Zorica
Radojičić, Ratko
Petrović, Vojislav M.
Ostala autorstva
Navarro, AnaVina, Jose
Davies, Kelvin J.A.
Cadenas, Enrique
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
,
© 2003 by the Univerzidad de Cadiz
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
In our study we investigated the effects of exogenous cadmium (Cd, 17 mg /day /kg b.m. in drinking water), coenzyme Q10 (CoQ 10, 16 mg/kg/dose CoQ10 dissolved in olive oil, i.m., every fifth day) and Cd+CoQ10 (i n above mentioned amou nt s) on antioxidant de fense enzyme activities (Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GST and GR) in interscapular hrown adipose tis sue (IBAT) of male two months old Wistar albin o rats during 30 days.
Cd induces significantly increased Mn SOD activity, while concomitant treatment of animals with Cd+CoQ10 reversed this change. The activity of CuZn SOD was significantly decreased
both in Cd and Cd+CoQ10 treated animals. CAT activity was sig nificantly increased in rats treated with Cd, whereas Cd+CoQ 10 normalized the activity of this enzyme. The activity of GSH-Px was significantly increased in all investigated groups of animals. Cd in duces an increased activity of GST, but by concomitant treatment of rats with Cd+CoQ10 the GST activity was retained . The activity of GR was significantly increased in Cd treated animals, while in rats treated with Cd+CoQ10 was signi fican tl y decre_ased.
It can be concluded that Cd induces oxidativ e stress and a l ter the activities of some antioxidant defense enzymes in IBAT of rats. It is also shown that CoQ 10 can normal ized Mn SOD, CAT a nd GST activities after Cd-induced changes .
Ključne reči:
Cadmium; Coenzyme Q10; Antioxidant defense enzymes; RatsFinansiranje / projekti:
- Serbian Ministry of Sciences, Yugoslavia, Grants No. 03E23 and 03E18.
U:
- Navarro A, Vina J, Davies KJA, Cadenas E, editors. Book of abstracts: Oxidants and antioxidants in biology; 2003 Feb 6-9; Cadiz, Spain. Cadiz: Univerzidad de Cadiz; 2003. p. 170.