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Pituitary ACTH cells in female rats after neonatal treatment with SRIH-14
dc.creator | Milošević, Verica | |
dc.creator | Nestorović, Nataša | |
dc.creator | Terzić, Milica | |
dc.creator | Ristić, Nataša | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Sekulić, Milka | |
dc.date.accessioned | 2023-09-25T11:10:00Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0239-8508 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/6053 | |
dc.description.abstract | The prolonged effects of neonatal SRIH-14 treatment on pituitary ACTH cells were investigated. Neonatal female rats were injected subcutaneously with SRIH (20 μg/100g b.w.) every 12 hours for five consecutive days (3rd-7th day of life). Groups of rats were then killed at the juvenile (16th day), peripubertal (38th day) or adult (80th day) stage. ACTH cells were visualized using the peroxidase-antiperoxidase immunocytochemical procedure. Morphometry and stereology were used to evaluate the ACTH-immunoreactive cell volume and volume density. The histological and immunocytochemical characteristics of ACTH cells in neonatally treated females were changed in all examined periods. Thus, SRIH-14 induced significant (p<0.05) decreases of ACTH cell volume in juvenile, peripubertal and adult rats by 26%, 39% and 14%, respectively, in comparison to the corresponding controls. The volume density of ACTH cells was also diminished (by 31%; p<0.05) at the juvenile stage in comparison with the corresponding controls. In peripubertal and adult rats, the volume densities of ACTH cells were somewhat lower (17% and 14%, respectively), but the decreases did not reach statistical significance. These findings suggest that neonatal treatment with SRIH-14 exerts a marked prolonged inhibitory effect on ACTH cell morphology extending to the adult period of life. | sr |
dc.language.iso | en | sr |
dc.publisher | VIA MEDICA | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143007/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Folia Histochemica et Cytobiologica | sr |
dc.subject | female rats | sr |
dc.subject | somatostatin | sr |
dc.subject | ACTH cells | sr |
dc.subject | development | sr |
dc.subject | immunocytochemistry | sr |
dc.title | Pituitary ACTH cells in female rats after neonatal treatment with SRIH-14 | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.rights.holder | © 2009 by the Polish Histochemical et Cytochemical Society | sr |
dc.citation.issue | 3 | |
dc.citation.volume | 47 | |
dc.identifier.doi | 10.2478/v10042-009-0104-1 | |
dc.identifier.pmid | 20164035 | |
dc.identifier.scopus | 2-s2.0-77149131549 | |
dc.identifier.wos | 000282021800021 | |
dc.citation.spage | 479 | |
dc.citation.epage | 484 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M23 |