Subcutaneously administrated genistein and daidzein decrease serum cholesterol and increase triglyceride levels in male middle-aged rats
2007
Autori:
Šošić-Jurjević, BrankaFilipović, Branko
Ajdžanović, Vladimir
Brkić, Dejan
Ristić, Nataša
Manojlović-Stojanoski, Milica
Nestorović, Nataša
Trifunović, Svetlana
Sekulić, Milka
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
©2007 by the Society for Experimental Biology and Medicine
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Nutritional supplements containing soybean phytoestrogens, the isoflavones genistein (G) and daidzein (D), are increasingly used as alternative therapy for osteoporosis, cancer, and cardiovascular and other diseases with a frequency that increases with advancing age. In this study we examined the effects of subcutaneous administration of either G or D on serum lipid levels in orchidectomized (Orx) and intact (IA) middle-aged male rats, which are experimental models of andropause. Sixteen-month-old Wistar rats were treated with 10 mg/kg and 30 mg/kg of either G or D. The control groups received testosterone, estradiol, or vehicle for 3 weeks, after which the total serum cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and total triglycerides (TT) were measured. Compared with the matching vehicle-treated controls, the higher doses of G and D and testosterone treatment significantly (P < 0.05) lowered the TC and lipoprotein cholesterol levels. The greatest effect was observed regarding LDL-C in both Orx and IA males after G and D treatments, in which LDL-C decreased by more than 30%. The lower isoflavone doses induced a significant cholesterol-lowering effect (P < 0.05) only in the Orx group. Like the estradiol treatment, the higher doses of G and D increased the TT levels in both rat models by more than 50% (P < 0.05). The lower doses of isoflavones increased TT only in the Orx group. In male middle-aged rats, injections of higher doses of G and D decreased the serum cholesterol levels, as did testosterone injection, and brought about an increase in serum triglycerides similar to that observed after estradiol treatment.
Ključne reči:
sex steroids; cholesterol; rats; middle age; isoflavones; triglyceridesIzvor:
Experimental biology and medicine (Maywood, N.J.), 2007, 232, 9, 1222-1227Finansiranje / projekti:
- Uticaj fitoestrogena, steroidnih i peptidnih hormona na ćelije neuroendokrinog sistema (RS-MESTD-MPN2006-2010-143007)
DOI: 10.3181/0703-BC-82
ISSN: 1535-3702
PubMed: 17895530