Physiological strategies in wild rodents: immune defenses of commensal rats
2023
Аутори:
Mirkov, IvanaTucović, Dina
Kulaš, Jelena
Malešević, Anastasija
Kataranovski, Dragan
Kataranovski, Milena
Popov Aleksandrov, Aleksandra
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2023 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
The importance of issues associated with urban/commensal rats and mice (property damage, management costs,
and health risks) press upon research on these animals. While the demography of commensal rodents is mostly
studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this
respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host
survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke
diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to
the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers
of more zoonotic agents, rats’ immunity is studied mainly in that context. Some of these zoonotic agents cause
chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance
versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis
of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in
commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some
light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent
ecology.
Кључне речи:
commensal rats and mice; immunopathology; infection; inflammation; toleranceИзвор:
Integrative Zoology, 2023, 1-21Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.1111/1749-4877.12766
ISSN: 1749-4877
PubMed: 37814602