The Effects of Endocrine Disruptors on Female Gonadal Axis: an Update
2023
Authors:
Macut, ĐuroOpalić, Milica
Popović, Bojana
Ognjanović, Sanja
Bjekić-Macut, Jelica
Livadas, Sarantis
Petrović, Tijana
Hrnčić, Dragan
Stanojlović, Olivera
Vojnović Milutinović, Danijela
Micić, Dragan
Mastorakos, George
Document Type:
Article (Published version)
,
© 2023 by the Acta Endocrinologica Foundation
Metadata
Show full item recordAbstract:
Endocrine disruptors (EDs) are considered to have an impact on the function of reproductive axis at different levels as well on reproductive organs in both sexes. Complexity of female reproductive system influenced with various stressors including EDs lead to morphological and functional alterations. This is resulting in modulation of neuroendocrine regulation with consequent developmental irregularities and derangements, causative infertility, endometriosis as well as premature ovarian insufficiency or polycystic ovary syndrome. A number of experimental clues was obtained on female animal models using various EDs such as synthetic estrogens and phytoestrogens, neurotransmitters, pesticides or various chemicals. These substances lead towards consequent derangement of the neuroendocrine control of reproduction from early phases of reproductive development towards different phases of adult reproductive period. This text will address some novel insights into the effects of EDs on neuroendocrine regulation of gonadal axis, effects on ovaries as well on endometrium during implantation period.
Keywords:
endocrine disruptors; female reproduction; infertility; neuroendocrine regulation; ovary; endometrium; implantationSource:
Acta Endocrinologica (Bucharest), 2023, 19, 1, 81-86Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200110 (University of Belgrade, Faculty of Medicine) (RS-MESTD-inst-2020-200110)
DOI: 10.4183/aeb.2023.81
ISSN: 1841-0987
PubMed: 37601725