Effect of atypical antipsychotics on antioxidant enzyme activities in human erythrocytes (in vitro study)
2013
Аутори:
Miljević, ČedoNikolić-Kokić, Aleksandra
Nikolić, Milan
Niketić, Vesna
Spasić, Mihajlo
Lečić-Toševski, Dušica
Blagojević, Duško
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2012 John Wiley & Sons, Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Objective This study was set out to examine the impact of atypical antipsychotic drugs: aripiprazole, clozapine, ziprasidone, olanzapine, quetiapine, sertindole and amisulpride on the activity of antioxidant defence enzymes in human erythrocytes in vitro. Methods Cu,Zn-superoxide dismutase (SOD1), catalase (CAT), selenium-dependent glutathione peroxidase and glutathione reductase activities were determined after drugs incubation with blood of 15 apparently healthy non-smoking male volunteers (ages 23–39) for 1 h at 37 C. Results A statistically significant increase in SOD1 activity was found in samples incubated with aripiprazole (p<0.01) and quetiapine (p<0.05) compared with incubated control. SOD1 activity profile following native polyacrylamide gel electrophoresis indicates that aripiprazole and quetiapine protect enzyme activity from inhibition with hydrogen peroxide. Our results showed that sertindole decreases activity of CAT comparing with control non-treated erythrocytes. Moreover, in sertindole treated erythrocytes, negative correlation between SOD1 and glutathione peroxidase activities was found. Increased amount of hydrogen peroxide in such situation may leave erythrocytes and transform their role in circulation from anti-oxidative to pro-oxidative. Conclusions Our results indicate that mechanism through sertindole could express its in vivo toxic effects and point toward possible (neuro) protective effects of aripiprazole and quetiapine.
Кључне речи:
atypical antipsychotics;; oxidative stress;; anti-oxidant defence enzymesИзвор:
Human Psychopharmacology: Clinical and Experimental, 2013, 28, 1, 1-6Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.1002/hup.2272
ISSN: 0885-6222
PubMed: 23124725