Sinteza novih derivata artemizinina sa antitumorskom aktivnošću na rezistentne ćelije raka
Synthesis of novel artemisinin derivatives with anticancer activity against multidrug-resistant cancer cells
2023
Authors:
Koračak, Ljiljana K.Lupšić, Ema
Jovanović, Mirna
Novaković, Miroslav
Pešić, Milica
Opsenica, Igor M.
Contributors
Šojić Merkulov, DanielaDocument Type:
Conference object (Published version)
,
© 2023 by the Serbian Chemical Society
Metadata
Show full item recordAbstract:
In addition to being used for the effective treatment of malaria, artemisinin and derivatives also exhibit anticancer activity. The importance of the pyrimidine scaffold is evidenced by its presence in natural products and approved drugs, as well as in biologically active compounds. In this study, we report the synthesis of novel hybrid molecules comprising two pharmacophores and their activity against sensitive and multidrug‐resistant human non‐small cell lung carcinoma cells.
Keywords:
artemisinin; MDRFunding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200288 (Innovation Center of the Faculty of Chemistry) (RS-MESTD-inst-2020-200288)
In:
- Šojić Merkulov D, editor. Book of Abstracts and Proceedings: 59th meeting of the Serbian Chemical Society; 2023 Jun 1-2; Novi Sad, Serbia. Belgrade: Serbian Chemical Society; 2023. p. 73.