Uticaj delecije gena Mif na razvoj gojaznosti i steatoze jetre kod miševa na režimu ishrane obogaćene fruktozom
The effects of deletion of the Mif gene on the development of obesity and hepatic steatosis on mice on fructose enriched diet
2023
Document Type:
Book part (Published version)
,
© 2023 by the Institute of Molecular Genetics and Genetic Engineering, University of Belgrade
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Show full item recordAbstract:
Chronic low-grade inflammation plays an important role in the development of metabolic disorders such as obesity and dyslipidemia, which are often induced by a fructose-enriched diet and are risk factors for the development of hepatic steatosis and type 2 diabetes. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that, in addition to its role in regulating the immune response, can regulate metabolic processes and the release of insulin from the pancreas; however its role in metabolic inflammation is not well understood. In addition, mice with a deleted Mif gene were found to have altered sensitivity to insulin and glucose. Therefore, the focus of this work was to better understand the molecular mechanisms of the metabolic effects of MIF and to elucidate the controversial role of this cytokine in the development ofdyslipidemia in the liver and visceral adipose tissue of mice on fructose-enriched diet.
Keywords:
macrophage migration inhibitory factor; fructose; visceral adipose tissue; liver; glucocorticoid hormones; lipid metabolism; insulin resistanceSource:
Trends in molecular biology, 2023, 3, 151-166Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)