Impact of gut microbiota on immune reactions relevant to lung pathologies
2023
Authors:
Popović, DušankaMalešević, Anastasija
Tucović, Dina
Kulaš, Jelena
Popov Aleksandrov, Aleksandra
Mirkov, Ivana
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Bacterial microbiota of the gastrointestinal tract is known to prevent the invasion of
pathogenic microorganisms and regulate intestinal permeability, digestion, metabolism, and
immune response. It affects function, homeostasis, and disease outcomes in the gastrointestinal
tract and extra-intestinal sites such as the lungs. This review summarizes the currently available
knowledge regarding the gut-lung axis. The association of bacterial composition and/or dysbiosis
in the gut with asthma, chronic obstructive lung disease, cystic fibrosis, recurrent respiratory tract
infections, and lung cancer in humans is highlighted, as well as data obtained from animal models
of pulmonary inflammation, which indicated that modulation of immune system activity lies at
the base of this interaction. Additionally, the potential use of prebiotics, probiotics, and postbiotics
in the treatment of lung inflammation is presented.
Keywords:
gut bacterial microbiota; gut-lung axis; lung inflammation; bakterijska mikrobiota creva; osa creva-pluća; inflamacija u plućimaSource:
Arhiv za farmaciju, 2023, 73, 6, 463-483Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)