Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance
2024
Authors:
Popov Aleksandrov, AleksandraTucović, Dina
Kulaš, Jelena
Popović, Dušanka
Kataranovski, Dragan
Kataranovski, Milena
Mirkov, Ivana
Document Type:
Article (Published version)
,
© 2024 Elsevier Inc.
Metadata
Show full item recordAbstract:
The use of anticoagulant rodenticides (ARs) is one of the most commonly employed management methods for
pest rodents. ARs compete with vitamin K (VK) required for the synthesis of blood clotting factors in the liver,
resulting in inhibition of blood coagulation and often animal death due to hemorrhage. Besides rodents (target
species), ARs may affect non-target animal species and humans. Out of hemostasis disturbance, the effects of ARs
may be related to the inhibition of proteins that require VK for their synthesis but are not involved in the
coagulation process, to their direct cytotoxicity, and their pro-oxidant/proinflammatory activity. A survey of the
cellular and molecular mechanisms of these sublethal/asymptomatic AR effects is given in this review. Data from
field, clinical, and experimental studies are presented. Knowledge of these mechanisms might improve hazard
characterization and identification of potential ecotoxicological risks associated with ARs, contributing to a safer
use of these chemicals.
Keywords:
Anticoagulant rodenticides; Vitamin K antagonism; Effects unrelated to hemostasis; Direct cytotoxicity; Pro-oxidant/pro-inflammatory activitySource:
Comparative Biochemistry and Physiology, Part C, 2024, 277, 109841-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)