Steroidal hydrazones as antimicrobial agents: biological evaluation and molecular docking studies
2024
Authors:
Marlani, MaiaNadaraia, Nanuli
Barbakadze, Nana
Amiranashvili, Lela
Kakhabrishvili, M
Petrou, Anthi
Carević, Tamara
Glamočlija, Jasmina
Geronikaki, Athina
Document Type:
Article (Published version)
,
© 2024 Taylor & Francis
Metadata
Show full item recordAbstract:
Most of pharmaceutical agents display several or even many biological activities. It is obvious that testing even one compound for thousands of biological activities is a practically not reasonable task. Therefore, computer-aided prediction is the method of choice for the selection of the most promising bioassays for particular compounds. Using PASS Online software, we determined the probable antimicrobial activity of the 31 steroid derivatives. Experimental testing of the antimicrobial activity of the tested compounds by microdilution method confirmed the computational predictions. Furthermore, P. aeruginosa and C. albicans biofilm formation was investigated. Compound 11 showed a biofilm reduction by 42.26% at the MIC of the tested compound. The percentages are lower than ketoconazole, but very close to its activity.
Keywords:
antimicrobial; PASS; antifungal activity; docking; steroidal hydrazonesSource:
SAR and QSAR in Environmental Research, 2024, 35, 2, 137-155
DOI: 10.1080/1062936X.2024.2309183
ISSN: 1062-936X
PubMed: 38312087