Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease
2024
Аутори:
Šaponjić, JasnaMejías, Rebeca
Nikolovski, Neda
Dragic, Milorad
Canak, Asuman
Papoutsopoulou, Stamatia
Gürsoy-Özdemir, Yasemin
Fladmark, Kari
Ntavaroukas, Panagiotis
Bayar Muluk, Nuray
Zeljkovic Jovanovic, Milica
Fontán-Lozano, Ángela
Comi, Cristoforo
Marino, Franca
Тип документа:
Приказ (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Parkinson’s disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological
approaches used to study the changes in central and peripheral immunity in PD, the advantages and
limitations of the techniques, and their applicability to humans. Although a single animal model
cannot replicate all pathological features of the human disease, neuroinflammation is present in
most animal models of PD and plays a critical role in understanding the involvement of the immune
system (IS) in the pathogenesis of PD. The IS and its interactions with different cell types in the
central nervous system (CNS) play an important role in the pathogenesis of PD. Even though culture
models do not fully reflect the complexity of disease progression, they are limited in their ability to
mimic long-term effects and need validation through in vivo studies. They are an indispensable tool
for understanding the interplay between the IS and the pathogenesis of this disease. Understanding
the immune-mediated mechanisms may lead to potential therapeutic targets for the treatment of PD.
We believe that the development of methodological guidelines for experiments with animal models
and PD patients is crucial to ensure the validity and consistency of the results.
Кључне речи:
Parkinson’s disease; immune systems; neuroinflammation; neurodegeneration; peripheral immune cells; animal models; cellular modelsИзвор:
International Journal of Molecular Sciences, 2024, 25, 8, 4330-Финансирање / пројекти:
- COST Action IMMUPARKNET (CA 21117)