Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities
Authors:
Morante-Carriel, JaimeŽivković, Suzana
Nájera, Hugo
Sellés-Marchart, Susana
Martínez-Márquez, Ascensión
Martínez-Esteso, María José
Obrebska, Anna
Samper-Herrero, Antonio
Bru-Martínez, Roque
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Prenylated flavonoids (PFs) are natural flavonoids with a prenylated side chain attached to the flavonoid skeleton. They have great potential for biological activities such as anti-diabetic, anti-cancer, antimicrobial, antioxidant, anti-inflammatory, enzyme inhibition, and anti-Alzheimer’s effects. Medicinal chemists have recently paid increasing attention to PFs, which have become vital for developing new therapeutic agents. PFs have quickly developed through isolation and semi- or full synthesis, proving their high value in medicinal chemistry research. This review comprehensively summarizes the research progress of PFs, including natural PFs from the Moraceae family and their pharmacological activities. This information provides a basis for the selective design and optimization of multifunctional PF derivatives to treat multifactorial diseases.
Keywords:
flavonoids; prenylated compounds; Moraceae family; bioactivitiesSource:
Plants, 2024, 13, 9, 1211-Funding / projects:
- Spanish Ministry of Science and Innovation, MCIN/AEI/10.13039/501100011033
- Valencian Conselleria d’Innovació, Universitats, Ciencia y Societat Digital grant CIAICO/2021/167
- RDF A way of making Europe, and European Union NextGenerationEU/PRTR grants PID2020-113438RB-I00 and TED2021-129617B-I00
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)