Soy extract and soy isoflavones do not affect serum cholesterol and triglyceride levels in orchidectomized young adult rats
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2013
Authors:
Šošić-Jurjević, Branka![](/themes/MirageIBISS/images/orcid.png)
Filipović, Branko
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Trifunović, Svetlana
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Ajdžanović, Vladimir
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Nestorović, Nataša
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Jarić, Ivana
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Milošević, Verica
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Contributors
Đurić, DraganJakovljević, Vladimir
Document Type:
Conference object (Published version)
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© 2013 by the Serbian Physiological Society
Metadata
Show full item recordAbstract:
Soy-based dietary supplements are promoted as a "natural" way to reduce menopausal symptoms, and to decrease the risk of heart disease, osteoporosis and breast cancer in women. Studies published so far provide contradictory information on these effects. Observed health benefits of using soy supplements are minimal. By preventing prostate cancer development, soy isoflavones actually have more impact on health of the male population; clinical and experimental data on serum cholesterol levels and bones in males are still incomplete. We have previously demonstrated that purified isoflavones, genistein (G) and daidzein (D), decrease serum cholesterol levels and increase serum triglycerides in middle-aged rats. To further examine whether the animals' age has an impact on the obtained results, we applied the same experimental design on young adult male rats. Orchidectomized (Orx) 3 month-old Wistar rats (which were fed soy-free diet) were subcutaneously treated with 10 mg/kg or 30mg/kg of G, D, or soy extract enriched with isoflavones (40%). The control groups received vehicle, testosterone or estradiol for three weeks, after which the total serum cholesterol (TC), low density lipoprotein, high density lipoprotein and total triglycerides (TT) were measured. Compared to the matching vehicletreated controls, the testosterone treatment significantly (p<0.05) lowered the TC levels, while estradiol significantly increased the TC levels. Estradiol treatment increased (p<0.05) the TT levels. Injections of neither G, D nor soy extract did not affect the serum cholesterol and triglyceride levels. In conclusion, cholesterollowering effect of soy isoflavones was lesser in young adult than in middle-aged rats.
Keywords:
soy extract; cholesterol and triglyceride levels; ratsFunding / projects:
- The effects of select plant extracts, phytoestrogens, steroid and peptide hormones on the rat neuroendocrine system (RS-MESTD-Basic Research (BR or ON)-173009)
In:
- Đurić D, Jakovljević V, editors. Abstract book with final program: Joint Meeting of National Physiological Societies: New frontiers in physiological research - from scientific truth via friendship to the art; 2013 Jun 20-22; Kovačica, Serbia. Belgrade: Serbian Physiological Society; 2013. p. 41.