Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses
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2024
Autori:
Manojlović-Stojanoski, Milica![](/themes/MirageIBISS/images/orcid.png)
Borković-Mitić, Slavica
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Nestorović, Nataša
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Ristić, Nataša
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Stefanović, Radomir
Stevanović, Magdalena
Filipović, Nenad
Stojsavljević, Aleksandar
Pavlović, Slađan
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Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
To compare the effects of organic selenium nanoparticles (SeNPs, Se0) and inorganic
sodium selenite (NaSe, Na2SeO3, Se4+) on the antioxidant response in maternal and fetal rat liver,
pregnant females were treated with two forms of selenium (Se) at equivalent doses during gestation
(0.5 mg SeNPs or 0.5 mg NaSe/kg body weight/day). Structural parameters of the liver of gravid
females and their fetuses were examined in a sex-specific manner. The oxidative stress parameters
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase
(GR), glutathione S-transferase (GST), total glutathione (GSH) and sulfhydryl groups (SH) were
established. In addition, the Se concentration was determined in the blood, liver, urine and feces
of the gravid females and in the liver of the fetuses. The structure of the liver of gravid females
remained histologically the same after supplementation with both forms of Se, while the oxidative
stress in the liver was significantly lower after the use of SeNPs compared to NaSe. Immaturity of
fetal antioxidant defenses and sex specificity were demonstrated. This study provides a detailed
insight into the differences in the bioavailability of the nano form of Se compared to sodium selenite
in the livers of pregnant females and fetuses.
Ključne reči:
antioxidant response; selenium nanoparticles; sodium selenite; pregnancy; fetuses; liver; histology; oxidative stress parameters; sex differencesIzvor:
Antioxidants, 2024, 13, 7, 756-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200175 (Institut tehničkih nauka SANU, Beograd) (RS-MESTD-inst-2020-200175)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200288)