Secondary metabolites from endangered Gentiana, Gentianella, Centaurium, and Swertia species (Gentianaceae): promising natural biotherapeutics
2020
Autori:
Tovilović-Kovačević, GordanaZogović, Nevena
Krstić Milošević, Dijana
Ostala autorstva
Ozturk, MunirEgamberdieva, Dilfuza
Pešić, Milica
Tip dokumenta:
Poglavlje u monografiji (Objavljena verzija)
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© 2020 Elsevier Inc.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Gentianaceae have a long history of use as traditional remedies for treatment of various ailments. The medicinal properties of crude herbal drug are attributed to bitter glycosides, flavonoids, and xanthones, the main plant secondary metabolites. These plant-derived molecules, especially naturally occurring xanthones, possess a broad spectrum of bioactivity like anticarcinogenic, antimicrobial, neuroprotective, antidiabetic, cardio-protective. The most of Gentianaceae species are rare and endangered by uncontrolled overharvesting and influences of various environmental factors (habitat loss, climate change, and invasive species spreading). Decline of Gentianaceae species poses a high risk to the loss of enormous diversity of potentially bioactive compounds. In this chapter we will summarize pharmacological activities of identified secondary metabolites from endangered species belonging to four Gentianaceae genera (Gentiana, Gentianella, Centaurium, Swertia), as well as importance of biodiversity conservation in context of their biotherapeutic potential.
Ključne reči:
xanthones; iridoids; flavonoids; pharmacological activity; endangered species; biodiversityFinansiranje / projekti:
- Uloga autofagije u regulaciji smrti tumorskih ćelija (RS-MESTD-Basic Research (BR or ON)-173053)
- Biotehnologija in vitro - gajene, lekovite i ugrožene biljne vrste (RS-MESTD-Basic Research (BR or ON)-173015)
- Biološki mehanizmi, nutritivni unos i status polinezasićenih masnih kiselina i folata: Unapređenje ishrane u Srbiji (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
U:
- Ozturk M, Egamberdieva D, Pešić M. Biodiversity and Biomedicine: Our Future. London: Academic Press; 2020. p. 335-84.