TY  - JOUR
AU  - Lukovac, Tanja
AU  - Aleksić Hil, Olivera
AU  - Popović, Milka
AU  - Jovanović, Vitomir
AU  - Savić, Tatjana
AU  - Pavlović, Aleksandra
AU  - Pavlović, Dragan
PY  - 2024
UR  - https://www.mdpi.com/2227-9067/11/4/497
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6704
AB  - The current diagnosis of attention deficit hyperactivity disorder (ADHD) is based on history, clinical observation, and behavioral tests. There is a high demand to find biomarkers for the diagnosis of ADHD. The aim of this study is to analyze the serum profiles of several biomarkers, including homocysteine (Hcy), vitamin B12, vitamin D, ferritin, and iron, in a cohort of 133 male subjects (6.5–12.5 years), including 67 individuals with an ADHD diagnosis based on DSM-V criteria and 66 age-matched healthy boys (healthy controls, HC). Assessments for ADHD included the Iowa Conners’ Teacher Rating Scale (CPRS) and the ADHDT test, as well as cognitive assessments using the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the TROG-2 language comprehension test. Hcy and iron were quantified using spectrophotometry, while vitamin B12 and total 25-hydroxy vitamin D levels were determined using an electrochemiluminescence immunoassay (ECLIA) and ferritin was measured using a particle-enhanced immunoturbidimetric assay. The results showed significantly increased Hcy levels and decreased vitamin B12 levels in ADHD patients compared to HCs. Multiple logistic regression analysis indicated that Hcy is a potential prognostic indicator for ADHD. These results suggest that elevated homocysteine and decreased vitamin B12 may serve as markers for the diagnosis and prognosis of ADHD.
PB  - Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI)
PB  - Basel: MDPI
T2  - Children (Basel)
T1  - Serum biomarker analysis in pediatric ADHD: Implications of homocysteine, vitamin B12, vitamin D, ferritin, and iron levels
IS  - 4
VL  - 11
DO  - 10.3390/children11040497
SP  - 497
ER  - 

@article{
author = "Lukovac, Tanja and Aleksić Hil, Olivera and Popović, Milka and Jovanović, Vitomir and Savić, Tatjana and Pavlović, Aleksandra and Pavlović, Dragan",
year = "2024",
abstract = "The current diagnosis of attention deficit hyperactivity disorder (ADHD) is based on history, clinical observation, and behavioral tests. There is a high demand to find biomarkers for the diagnosis of ADHD. The aim of this study is to analyze the serum profiles of several biomarkers, including homocysteine (Hcy), vitamin B12, vitamin D, ferritin, and iron, in a cohort of 133 male subjects (6.5–12.5 years), including 67 individuals with an ADHD diagnosis based on DSM-V criteria and 66 age-matched healthy boys (healthy controls, HC). Assessments for ADHD included the Iowa Conners’ Teacher Rating Scale (CPRS) and the ADHDT test, as well as cognitive assessments using the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the TROG-2 language comprehension test. Hcy and iron were quantified using spectrophotometry, while vitamin B12 and total 25-hydroxy vitamin D levels were determined using an electrochemiluminescence immunoassay (ECLIA) and ferritin was measured using a particle-enhanced immunoturbidimetric assay. The results showed significantly increased Hcy levels and decreased vitamin B12 levels in ADHD patients compared to HCs. Multiple logistic regression analysis indicated that Hcy is a potential prognostic indicator for ADHD. These results suggest that elevated homocysteine and decreased vitamin B12 may serve as markers for the diagnosis and prognosis of ADHD.",
publisher = "Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI), Basel: MDPI",
journal = "Children (Basel)",
title = "Serum biomarker analysis in pediatric ADHD: Implications of homocysteine, vitamin B12, vitamin D, ferritin, and iron levels",
number = "4",
volume = "11",
doi = "10.3390/children11040497",
pages = "497"
}

Lukovac, T., Aleksić Hil, O., Popović, M., Jovanović, V., Savić, T., Pavlović, A.,& Pavlović, D.. (2024). Serum biomarker analysis in pediatric ADHD: Implications of homocysteine, vitamin B12, vitamin D, ferritin, and iron levels. in Children (Basel)
Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI)., 11(4), 497.
https://doi.org/10.3390/children11040497

Lukovac T, Aleksić Hil O, Popović M, Jovanović V, Savić T, Pavlović A, Pavlović D. Serum biomarker analysis in pediatric ADHD: Implications of homocysteine, vitamin B12, vitamin D, ferritin, and iron levels. in Children (Basel). 2024;11(4):497.
doi:10.3390/children11040497 .

Lukovac, Tanja, Aleksić Hil, Olivera, Popović, Milka, Jovanović, Vitomir, Savić, Tatjana, Pavlović, Aleksandra, Pavlović, Dragan, "Serum biomarker analysis in pediatric ADHD: Implications of homocysteine, vitamin B12, vitamin D, ferritin, and iron levels" in Children (Basel), 11, no. 4 (2024):497,
https://doi.org/10.3390/children11040497 . .